Left Ventricle Restoration in End Stage Ischemic Dilated Cardiomyopathy

Left ventricle restoration in end stage ischemic dilated cardiomyopathy

Background Patients with end stage dilated cardiomyopathy exhibit extensive remodeling of the left ventricle, annular dilation, and significant mitral and tricuspid regurgitation. These changes increase perioperative morbidity and mortality, and emphasize patient candidacy for heart transplantation. We previously published that Reductive Annuloplasty of Double (mitral and tricuspid) Orifices co...

Treatment of end stage dilated cardiomyopathy.

Patients should be referred for cardiac transplantation only after all other means of management of congestive heart failure have been attempted and have been unsuccessful (table 3). An adequate therapeutic trial of conventional and experimental agents including beta blockade and vesnarinone should be completed and be shown to be unsuccessful before transplantation is considered in patients in ...

simultaneous left ventricle and left atrial appendage thrombi in a patient with dilated cardiomyopathy

In-depth proteomic profiling of left ventricular tissues in human end-stage dilated cardiomyopathy

Dilated cardiomyopathy (DCM) is caused by reduced left ventricular (LV) myocardial function, which is one of the most common causes of heart failure (HF). We performed iTRAQ-coupled 2D-LC-MS/MS to profile the cardiac proteome of LV tissues from healthy controls and patients with end-stage DCM. We identified 4263 proteins, of which 125 were differentially expressed in DCM tissues compared to LV ...

Autoimmune markers are undetectable in end stage idiopathic dilated cardiomyopathy.

BACKGROUND Autoreactive humoral and cellular immune responses may be involved in the pathogenesis of idiopathic dilated cardiomyopathy (IDC). Certain human leucocyte antigens (HLA) could also be linked to the development of IDC. AIM To determine whether various markers of autoimmunity are present in the final phase of the disease, to substantiate the role of an autoimmune process in IDC. ME...